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Large doses of dl-alpha tocopheryl acetate (Vitamin E) have been reported to increase bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants.
However, it has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens. The clinical significance of these effects is not known. A higher incidence of necrotizing enterocolitis has been noted in premature infants weighing less than 1.5 kg treated with vitamin E.
